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Breast Cancer

Breast cancer and lung cancer are both primary cancers, and eliminating residual cancer cells is fundamental

时间：2026-04-22　人气：

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Overview of the condition

Ms. Ren underwent radical surgery at 301 Hospital in April 2014 due to a suspected malignant breast lesion. Postoperative pathology revealed invasive carcinoma of the left breast, SBR grade II, with a tumor size of 3.5cmx2cmx1.7cm. The cancer tissue had invaded surrounding fibrous tissue, and intravascular cancer thrombus was observed. No metastatic cancer was found in axillary lymph nodes (0/32).

Following surgery, she received four cycles of chemotherapy with epirubicin and cyclophosphamide, and after half a year of tamoxifen treatment, she switched to endocrine therapy with fulvestrant and leuprolide, during which she also took exemestane for six months.

During a follow-up CT scan in 2021, a malignant nodule was found in the lingular segment of the left upper lobe of the lung. She underwent surgical treatment, including endoscopic resection of the lingular segment of the left upper lobe and lymph node dissection. Postoperative pathology showed invasive adenocarcinoma in the lingular segment of the left upper lobe, non-mucinous type, with a tumor diameter of 0.7cm. Diffuse cancer thrombus was found in the pulmonary alveoli surrounding the tumor, and no cancer metastasis was observed in regional lymph nodes. Genetic testing revealed mutations in BRACK2 and EGFR19. She has been taking the targeted drug Icotinib since her lung surgery.

Department

Small

Knowledge

Recognition

EGFR gene

The EGFR gene is a type of gene that expresses epidermal growth factor receptors, promoting normal cell division and proliferation under physiological conditions. However, in some cases, mutations in proto-oncogenes can lead to the development of tumors, with a higher incidence in non-smoking female lung adenocarcinoma. Typically, mutations in individual exons of EGFR make lung adenocarcinoma more sensitive to specific targeted drugs. Ms. Ren chose the targeted drug Icotinib for her postoperative treatment.

Both of Ms. Ren's primary tumors were discovered in a timely manner and underwent surgical removal. However, the appearance of different tumors twice has left Ms. Ren deeply concerned about the potential resurgence of the disease. After extensive research, Ms. Ren and her family learned about Professor Zhang Minghui's NKT technology at Tsinghua University School of Medicine through a friend's recommendation, and carefully reviewed the demonstrated cases of NKT cell therapy, particularly hoping to try it to reduce the risk of tumor recurrence and delay the occurrence of recurrence and metastasis.

After reviewing Ms. Ren's medical records, Professor Zhang Minghui made the following analysis and judgment:

1. The patient has successively suffered from breast cancer and lung cancer, indicating a special constitution with dual primary cancers.

2. Fortunately, both tumors were discovered in a timely manner and underwent surgery. After breast cancer surgery, a stable period of five years has been achieved, but one cannot be complacent. The pathology after lung cancer surgery indicated diffuse cancer thrombus in the alveolar spaces surrounding the tumor, indicating tumor infiltration into the alveolar spaces and a high risk of recurrence and metastasis.

3. NKT therapy utilizes powerful immune cells to eliminate tumor cells that may remain undetected in the body, with essentially no side effects. On the basis of conventional treatment, NKT therapy can effectively reduce the risk of tumor recurrence and delay the time of recurrence and metastasis.

Ms. Ren decided to undergo NKT cell immunotherapy in June 2021. The initial regimen was one course per two months, and after multiple follow-up examinations, no signs of recurrence or metastasis were observed.

As of February 2023, nine courses of treatment have been completed.

In terms of imagery

Tumor markers

The tumor marker results indicate that the recheck of tumor markers CEA and CA199 from January 25, 2021, to October 20, 2022, were within the normal range, and regular rechecks are recommended.

Conclusion and Comments

Ms. Ren's quality of life has been greatly improved. Her mental state is excellent, and she feels more energetic and vigorous than before, returning to her pre-illness state. She leads a normal life and works without being affected by the disease.

Ms. Ren underwent immediate surgical treatment after discovering the tumor, but new tumors appeared several years later. Her dual primary cancer constitution is special and cannot be taken lightly. Ms. Ren achieved the expected results after adopting NKT cell therapy. After more than two years of treatment, the latest assessment result remains stable with no progression observed.

A study was conducted on patients who were diagnosed with lung cancer after breast cancer surgery. The research showed that compared to patients diagnosed solely with lung cancer, those who were diagnosed with breast cancer first and then developed lung cancer have a high incidence of EGFR mutations. Radiotherapy and multiple CT scans after breast cancer surgery may be related to the re-diagnosis of lung cancer.

Popular science knowledge is provided for reference only. Individual patients should follow clinical medical advice.

Reference:< H415>

【1】Wang KY, Lee CS, Vempati P, Sharma R, Kohn N, Seetharamu N. Characteristics of Patients With Second Primary Lung Cancer Following Breast Cancer: A Retrospective Descriptive Study. Clin Lung Cancer. 2023 Apr 26:S1525-7304(23)00074-8. doi: 10.1016/j.cllc.2023.04.007. Epub ahead of print.

NKT Classic Case Review

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Breast cancer and lung cancer are both primary cancers, and eliminating residual cancer cells is fundamental

Overview of the condition

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